Melatonin is a naturally occurring hormone that is best known for its role in sleep regulation. After screening more than a thousand FDA-approved drugs several years ago, researchers determined that melatonin is a powerful antioxidant that blocks the release of enzymes that activate apoptosis, or programmed cell death.


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2013 - Melatonin slows als symptoms in mice

2006 - Reduced oxidative damage in ALS by high-dose enteral melatonin treatment

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[…] melatonin slowed disease progression by 25% or 73%, depending on the definition of “disease onset”, by the appearance of first tremor or failure on the rotarod, respectively.

Translating these findings to human ALS, we are aware that a cure by melatonin is unlikely. An increase in life expectancy, however, is a worth-while goal, specifically during the early stages of this disease.